One of the complications of severe burn injuries such as third degree burns is septic shock. Septic shock is a serious medical emergency that result from bacteremia ( bacteria in the bloodstream) leading to sepsis which is a systemic immune response to the bacterial toxins, this will lead to a dramatic drop in blood pressure leading to decrease tissue perfusion and decrease oxygen and nutrient supply to the tissues. Septic shock is the number one cause of death in intensive care units and the 13th most common cause of death in U.S (Parrillo, 1990 and US CDC). The mortality rate may reach up to 50%.
Septic shock can cause multiple organ dysfunction syndrome (multiple organ failure) including respiratory system failure and may cause death. Sepsis can be caused by other infectious microorganisms other than bacteria such as fungus and viruses. Septic shock occurs most often in children, elderly and immunocompromised individuals as their immune system is weakened and can’t effectively with infection. Infection can be localized to a particular site but when the immune system is weakened or compromised, the infection can spread to the blood stream causing systemic infection, sepsis and septic shock.
Risk factors for septic shock may include: